Two sample MR report
SPATA20_Interstitial Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | -0.0369808 | 0.2350043 | 0.8894106 |
| Weighted median | 4 | 0.0206937 | 0.0099030 | 0.0366505 |
| Inverse variance weighted | 4 | 0.0204170 | 0.0087248 | 0.0192777 |
| Simple mode | 4 | 0.0213887 | 0.0134883 | 0.2109847 |
| Weighted mode | 4 | 0.0213046 | 0.0139279 | 0.2235903 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0648657 | 2 | 0.9680875 |
| Inverse variance weighted | 0.1246019 | 3 | 0.9887299 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0402971 | 0.164875 | 0.8297006 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 4.52e-05 | 0 | TRUE | 0.523151 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
